Adult:
Initially, 800-1600 mg, taken with each meal and based on serum phosphorus level: 5.5 to <7.5 mg/dL: 800 mg tid; 7.5 to <9 mg/dL: 1.2-1.6 g tid; ≥9 mg/dL: 1.6 g tid. Patients switching from calcium acetate based on current dosage: 667 mg tid: 800 mg tid; 1334 mg tid: 1.2-1.6 g tid; 2001 mg tid: 2-2.4 g tid. May adjust dose by 1 tab/meal at 2-wkly intervals. Max dose studied: 13 g/day.
Precautions
Dysphagia, swallowing disorders, severe GI motility disorders, or major GI tract surgery. Pregnancy and lactation. Monitor serum levels of calcium, bicarbonate and chloride. To be taken with meals and tablets should be swallowed intact.
Adverse Drug Reactions
Headache, infection, pain, hypertension, hypotension, thrombosis, diarrhoea, flatulence, dyspepsia, nausea, vomiting, constipation and cough. Pruritus, rash and abdominal pain.
Interactions
Concurrent admin decreases the absorption of ciprofloxacin. Not to be taken concurrently with oral medications in which the safety and efficacy would be significantly affected by its reduced bioavailability.
